Found a mechanism by which the caloric restriction reduces inflammation. This discovery will help combat inflammatory diseases based could
Fasting, but also simple food, decrease the inflammatory response. The message itself is not new, but now we know in part, the mechanism by which this occurs through the Yale School of Medicine, explained: Admission blocks calorie part of the immune system in disease autoimmune inflammatory involved to reduce, but also of Alzheimer’s disease, type 2 diabetes and atherosclerosis.
This diet and fasting had an anti-inflammatory effect is known but only partially. That, in fact, to adapt the immune system in response to glucose and a decrease in the presence of metabolites formed by oxidation of the fat was not clear. Just the researchers explain today in the journal Nature Medicine.
In the base of the anti-inflammatory mechanism of nutrition and have the effect of a compound is: beta-hydroxybutyrate (BHB). This metabolite – produced by the body in response to fasting, intense physical activity, restriction or reduction of the consumption of calorie carbohydrate – directly inhibits NLRP3, a component of inflammasome, a multiprotein complex that causes the inflammatory response in various diseases , as indicated. Mutations in NLRP3 genes are also involved in various inflammatory diseases.
For this reason, the researchers tested the effects of BHB in some mouse models of inflammatory diseases associated with mutations NLRP3 to note that this is capable of converting inflammation because they are capable as ketogenic diets (low -Carb) which increase the BHB levels in the blood. Metabolic continues the researcher, which is capable of the production of interleukin 1β (IL-1β) and interleukin 18 (IL-18), both pro-inflammatory cytokines mediated dall’inflammasoma reduce.
“I our results,” says Vishwa Deep Dixit Yale School of Medicine and director of studies “suggest that endogenous products such as BHB metabolites for low carb diets after strenuous exercise or fasting can the” dell ‘ inflammasoma NLRP3 reduce activities. “