A study in Switzerland “Sentinel” created cells that recognize the biomarker compounds of psoriasis and liberation that soften skin reactions. The study in Science Translational Medicine
synthetic cells that keep psoriasis in check. This is the “inventionthat may replace pills and injections constantly, so the treatment of an incurable disease revolutionizing earlier. In Science Translational Medicine researchers show at ETH Zurich, the genetically modified cells are able, rash function to recognize threatening illness, through the “inflammation of the next release of therapeutic compounds stop.” cell disease the metabolite recognize and coordinate a specific response, leading to the production of a therapeutic protein, which are delivered through the bloodstream, “says Martin Fussen ETH Zurich.
Psoriasis is a chronic skin disease, not contagious. Causesinflammation the upper dermis Although the causes are still unclear, the skin lesions are the result of an increase in small proteins, inflammatory cytokines. Today, the available drugs are mainly based on topical treatments, daily injections or oral therapies based on antibodies, but not critical, since the peaks of inflammation are often unpredictable. Fussen but said: “The synthetic cells constantly measure the inflammatory cytokine, so that they can confront and stop the occurrence of inflammation immediately.”
To create Choukr Lina and her team they went on human cells when they installed two types of chemical receptors that identify the presence of TNF and IL-22 The researchers then injected the mice capsules, each containing 200 synthetic cells. Upon detection of both cytokines, the cells were producing IL-4 dose IL-10 molecules and automatically activated anti-inflammatory drugs directly into the bloodstream. The results showed that not only the cells in the synthetic remarkably effective stop inflammation, but also cure existing scars.
Genetically modified cells were also tested in blood samples from some patients, demonstrating that the job properly. “We believe that people can act like that. But it is almost impossible to predict how the immune system can react because it is very different organizations, “said Berger foot. “We need the cooperation of doctors and donors to continue our clinical trials research and start to start.”